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Analysis of the nuclear localization signal of TRF1 in non-small cell lung cancer Biol. Res.
JIAN,HU; LI,SUN; LU-MING,WANG; SU-JUN,JIANG.
Several studies revealed a similar down-regulation of telomeric repeat binding factor 1 (TRF1) in tumors. We have previously reported the TRFl expression levels were down-regulation in non-small cell lung cancer (NSCLC). The regulation of TRFl localization is proposed to be important for the function and expression. The nuclear localization signal (NLS) and nuclear export signal (NES) are often important clues to localization of protein. The objective of the present study was to investigate the NLS and NES of TRFl in NSCLC patients. Thirty (30) patients with NSCLCs had undergone radical operations in The First Affiliated Hospital, College of Medicine, Zhejiang University. DNA sequences of NLSs and NESs were amplified by PCR. The PCR products were analyzed...
Tipo: Journal article Palavras-chave: Non-small cell lung cancer; Telomeric repeat binding factor 1; Nuclear of localization signal; Nuclear of export signal; DNA sequencing.
Ano: 2009 URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0716-97602009000200010
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